Evaluation of antimicrobial activity of curcumin and capsaicin-loaded solid lipid nanoparticle

Vivian Shinobu Kishimoto Nishihira, Bruno Stefanello Vizzotto, Thaís da Costa Orlando, Thobias Toniolo de Souza, Julio Rieger Lucchese, Luciane Rosa Feksa, Luciane Varini Laporta, Rodrigo Almeida Vaucher, Virginia Cielo Rech

Resumo


In recent research curcumin and capsaicin have been used as an antimicrobial agent; in addition, curcumin is considered a photosensitizer in antimicrobial photodynamic therapy (aPDT). However, both have low aqueous solubility, a characteristic that makes it difficult to use them in clinical trials, indicating a small use. To circumvent these problems, incorporating them into solid lipid nanoparticle (NLS) may allow for more efficient delivery. This study aims to evaluate the antimicrobial activity of solid lipid nanoparticles containing curcumin and capsaicin (NCC). For this evaluation, the antimicrobial activity analysis was performed through the minimum inhibitory concentration (MIC), diffusion disc and TFA. For MIC and aPDT, triphenyl tetrazolium chloride (TTC) was used as an indicator of oxidation, which differentiates metabolically active tissues from those that are not active. Several gram-negative and gram-positive bacteria were evaluated. Based on the results obtained from the three evaluations, it is concluded that NCC did not produce an antimicrobial effect on either gram-negative or gram-positive bacteria evaluated here.


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